Pancytopenia is a pathological condition in which the numerical reduction of all the cells present in the blood (erythrocytes, white blood cells and platelets) occurs. In other words, the simultaneous association of anemia, leukopenia and thrombocytopenia is created.
Pancytopenia is associated with several clinical conditions, such as aplastic anemia, myelodysplastic syndromes, myelofibrosis, leukemia and neoplastic infiltration of the bone marrow.
The most frequent causes also include serious infections, hemorrhages, thymoma and pathological increase in spleen activity (hypersplenism). Pancytopenia can also be seen in Gaucher disease, dyskeratosis congenita, and paroxysmal nocturnal hemoglobinuria.
Iatrogenic causes include ionizing radiation and chemotherapy for malignancies if the agent used induces bone marrow suppression.
Pancytopenia can also be induced by some drugs (including antifungals and antibiotics) and by exposure to toxic agents (e.g. arsenic intoxication).
Possible causes of pancytopenia
Pancytopenia is a common or probable symptom of these diseases
By clicking on the pathology you are interested in, you can read further information on its origins and the symptoms that characterize it. Pancytopenia can also be a typical symptom of other diseases, not included in our database and therefore not listed.
This guide is in no way intended to replace the opinion of doctors or other healthcare professionals responsible for the correct interpretation of symptoms, to whom we refer to obtain a more precise indication of the origins of any symptom.