Hypocalcemia is a reduction in total serum calcium concentration below 8.8 mg/dl (< 2.20 mmol/l), in the presence of normal plasma protein concentrations. This condition causes various manifestations, such as paresthesia, tetany and, if severe, convulsions, encephalopathy and heart failure.
Vitamin D deficiency may be secondary to inadequate dietary intake or reduced absorption due to hepatobiliary pathologies or intestinal malabsorption. The deficiency can also occur due to metabolic alterations, as happens with some drugs (e.g. phenytoin and rifampin), or following reduced skin synthesis, related to lack of exposure to sunlight and/or aging.
Hypocalcemia can also be induced by drugs used to treat hypercalcemia and anticonvulsants.
Other causes include reduced dietary calcium intake and/or absorption due to malnutrition, magnesium deficiency, hypoproteinemia, and acute hyperphosphatemia.
Hypocalcemia may also result from malabsorption, acute pancreatitis, septic shock, medullary thyroid carcinoma, rickets, and other bone diseases (such as hungry bone syndrome and bone-thickening metastases).
Possible causes of hypocalcemia
Hypocalcemia is a common or probable symptom of these diseases
By clicking on the pathology you are interested in, you can read further information on its origins and the symptoms that characterize it. Hypocalcemia can also be a typical symptom of other diseases, not included in our database and therefore not listed.
This guide is in no way intended to replace the opinion of doctors or other healthcare professionals responsible for the correct interpretation of symptoms, to whom we refer to obtain a more precise indication of the origins of any symptom.