Renal Colic - Drugs for the Treatment of Renal Colic

What Is Renal Colic: Drugs for the Treatment of Renal Colic, Causes, Symptoms and Complications,Treatment

Renal colic is an acute and violent pain in the ureter, characterized by very strong contractions of the kidneys. In addition to renal colic, intestinal, hepatobiliary, pancreatic and gastric colic are mentioned.


The severe pain associated with renal colic depends on the passage of stones in the ureter, responsible for the muscle spasm; however, colic can occur even in the absence of urinary flow obstruction. The synthesis of prostaglandins, responsible for pain, is favored by pressure violence, induced in turn by obstruction of the urinary tract.


Renal colic can cause variable symptoms: abdominal and lumbar pain – often spreading to the groin and genitals – hematuria (blood in the urine), fever, hypotension, intense sweating, nausea and vomiting.The information on Renal Colic – Medicines for the Treatment of Renal Colic is not intended to replace the direct relationship between health professional and patient. Always consult your doctor and/or specialist before taking Renal Colic – Medicines for the Treatment of Renal Colic.


It is necessary to underline that an isolated episode of renal colic should not be excessively alarming: in any case, it is a good idea to contact your GP, who will prescribe the useful tests to ascertain the nature of the colic. Recurrent renal colic, however, requires a specialist visit (urologist and nephrologist) and an appropriate pharmacological procedure.
The drugs are aimed at reducing painful symptoms and eliminating the causes that generated renal colic:NSAIDs pain relief therapy: it is advisable not to delay and to take the anti-inflammatory drug starting from the onset of symptoms, after consulting a doctor.

  • Ketorolac tromethamine (e.g. Toradol): used to relieve fever and pain associated with renal colic. The drug is available in the form of tablets or vials: administer 10 mg of active ingredient orally or intravenously/intramuscularly, 3-4 times a day for a period of less than or equal to 5 days. In case of severe pain, replace the drug with opioids.
  • Paracetamol or acetaminophen (e.g. Tachipirina, Buscopan compositum): in case of fever associated with renal colic, take the drug orally in the form of tablets, syrup, effervescent sachets or suppositories; it is recommended to take paracetamol at a dosage of 325-650 mg every 4-6 hours for 6-8 consecutive days, to reduce fever.
  • Pethidine (e.g. Petid C): for acute pain, take orally a dose equivalent to 50-150 mg every 4 hours, depending on the severity of the colic. For subcutaneous injection, administer 25-100 mg and repeat the application after 4 hours. For intramuscular injection, administer 0.5-2 mg of active ingredient per kilo of body weight. Alternatively, by slow intravenous infusion, it is recommended to administer the drug at a dosage of 25-50 mg (repeat after 4 hours).
  • Diclofenac (e.g. Fastum Painkiller, Dicloreum): preferable to pethidine. Take 50 mg of the drug orally 3 times a day (tablets); in some patients, an initial dose of 100 mg is required, then increasing to 50 mg. After the first day, the total daily dose should not exceed 150 mg.

Antispasmodic drugs (to be combined with NSAIDs): they are useful for relaxing the muscles of the genitourinary tract affected by colic. The administration of these drugs is useful for extracting the stone responsible for renal colic.

  • The Colic Antispasmin pharmaceutical specialty is made up of belladonna and papaverine hydrochloride: these two active ingredients are indicated to reduce the painful spastic symptoms associated with renal colic (spasms caused by contractions of the smooth muscles of the gastrointestinal tract). Belladonna (anticholinergic therapeutic action) reduces the contraction of smooth muscles, ensuring a significant reduction in spastic pain. Take 2-6 dragees – consisting of 10 mg of papaverine and 10 mg of belladonna – per day for medium pain caused by renal colic. In case of severity, take 1-3 tablets of 50 mg of papaverine and 10 mg of belladonna per day.

Antiemetics: in case of renal colic associated with nausea/vomiting, the administration of anti-nausea/antiemetic drugs is recommended. For example, the administration of Scopolamine butyl bromide (e.g. Addofix) is recommended, which is particularly useful for relieving spastic pain in the genitourinary and gastrointestinal tract.

Antibiotics: when colic is caused by bacterial infections, the doctor prescribes antibiotics to the patient, in order to remove the pathogens responsible for the infection.

Rest and an improvement in the patient’s diet and lifestyle are useful for completing therapeutic measures in the presence of renal colic.

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